In June 2012, the funding for the Cluster of Excellence "Precision Physics, Fundamental Interactions and Structure of Matter (PRISMA)" has been approved by the Joint Commission of the German Research Foundation and the German Council of Science and Humanities. PRISMA is one of two clusters in Germany dedicated to research into basic questions about the nature of the fundamental building blocks of matter and their importance for the physics of the Universe. The Cluster is funded by the German Research Foundation (DFG) and the State of Rhineland Palatinate.

PRISMA consists of leading research groups that work primarily in the areas of astroparticle, high-energy, and hadron physics, nuclear chemistry and precision physics with ultra-cold neutrons and ion traps. One of the main goals PRISMA is to realise various new key experiments to study the fundamental forces and limits of the Standard Model.

PRISMA is a joint initiative involving Johannes Gutenberg University Mainz, the Helmholtz Institute Mainz (HIM), and the GSI Helmholtz Center for Heavy Ion Research in Darmstadt.